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Monoclonal antibodies (mAbs) are laboratory-made proteins that mimic the immune system’s ability to fight harmful pathogens such as viruses, bacteria, or cancer cells. They are produced by identical immune cells that are cloned from a single parent cell, ensuring uniformity and specificity in targeting a particular antigen. Unlike polyclonal antibodies, which bind to multiple epitopes, monoclonal antibodies are highly specific, recognizing and binding to only one unique epitope on an antigen. This precision makes them powerful tools in both diagnostic applications and therapeutic treatments. They can be designed to block disease-related molecules, trigger immune responses against diseased cells, or deliver drugs directly to targeted tissues.
In healthcare, monoclonal antibodies have revolutionized the treatment of cancer, autoimmune disorders, infectious diseases, and more recently, viral outbreaks such as COVID-19. Several mAb therapies are approved for conditions like rheumatoid arthritis, breast cancer, and multiple sclerosis, offering patients more effective and targeted treatment options compared to conventional therapies. Beyond medicine, they are also used in research and diagnostic tests, such as pregnancy kits and laboratory assays. Despite their benefits, monoclonal antibodies can be expensive to produce and may sometimes cause immune reactions, but ongoing advancements in biotechnology are helping to improve their safety, accessibility, and affordability.
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